Chocolate for breakfast prevents circadian desynchrony in experimental models of jet-lag and shift-work.

ABSTRACT: Night-workers, transcontinental travelers and individuals that regularly shift their sleep timing, suffer from circadian desynchrony and are at risk to develop metabolic disease, cancer, and mood disorders, among others. Experimental and clinical studies provide evidence that food intake restricted to the normal activity phase is a potent synchronizer for the circadian system and can prevent the detrimental metabolic effects associated with circadian disruption. As an alternative, we hypothesized that a timed piece of chocolate scheduled to the onset of the activity phase may be sufficient stimulus to synchronize circadian rhythms under conditions of shift-work or jet-lag. In Wistar rats, a daily piece of chocolate coupled to the onset of the active phase (breakfast) accelerated re-entrain

SUBMITTER: Escobar C 

PROVIDER: S-EPMC7148329 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature