Giardia lamblia Decreases NF-κB p65^RelA Protein Levels and Modulates LPS-Induced Pro-Inflammatory Response in Macrophages.

ABSTRACT: The protozoan Giardia lamblia is the most common cause of parasitic gastrointestinal infection worldwide. The parasite developed sophisticated, yet not completely disclosed, mechanisms to escape immune system and growth in the intestine. To further understand the interaction of G. lamblia with host immune cells, we investigated the ability of parasites to modulate the canonical activation of mouse macrophages (Raw 264.7 cell line) and human monocyte-derived macrophages triggered by the TLR4 agonist, lipopolysaccharide (LPS). We observed that G. lamblia impairs LPS-evoked pro-inflammatory status in these macrophage-like cells through inhibition of cyclooxygenase-2 and inducible nitric oxide synthase expression and subsequent NO production. This effect was in part due to the activity of thre

SUBMITTER: Faria CP 

PROVIDER: S-EPMC7148380 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature