Association of Glomerular Hyperfiltration and Cardiovascular Risk in Middle-Aged Healthy Individuals.

ABSTRACT:

Importance

Glomerular hyperfiltration is associated with increased risk of cardiovascular disease in high-risk conditions, but its significance in low-risk individuals is uncertain.

Objective

To determine whether glomerular hyperfiltration is associated with increased cardiovascular risk in healthy individuals.

Design, setting, and participants

This was a prospective population-based cohort study, for which enrollment took place from August 2009 to October 2010, with follow-up available through March 31, 2016. Analysis of the data took place in October 2019. The cohort was composed of 9515 healthy individuals, defined as individuals without hypertension, diabetes, cardiovascular disease, estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2, or stati

SUBMITTER: Dupuis ME 

PROVIDER: S-EPMC7148438 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature