Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?

ABSTRACT: Cancers are one of the major challenges faced by modern medicine both because of their impact in terms of the amount of cases and of the ineffectiveness of therapies used today. A concrete support to the fight against them can be found in the analysis and understanding of the molecular mechanisms involving molecular chaperones. In particular, HSP60 and HSP10 seem to play an important role in carcinogenesis, supporting tumours in their proliferation, survival, and metastasis. Efforts must be directed toward finding ways to eliminate or block this "mistaken" chaperone. Therefore, the scientific community must develop therapeutic strategies that consider HSP60 and HSP10 as the possible target of an anti-tumoural treatment and not only as diagnostic biomarkers, since they contribute to the evo

SUBMITTER: Fucarino A 

PROVIDER: S-EPMC7149434 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature