The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids.

ABSTRACT: The causes of hypertension are complex and involve both genetic and environmental factors. Environment changes during fetal development have been linked to adult diseases including hypertension. Studies show that timed in utero exposure to the synthetic glucocorticoid (GC) dexamethasone (Dex) results in the development of hypertension in adult rats. Evidence suggests that in utero stress can alter patterns of gene expression, possibly a result of alterations in the topology of the genome by epigenetic markers such as DNA methyltransferases (DNMTs) and histone deacetylases (HDACs). The objective of this study was to determine the effects of epigenetic regulators in the fetal programming and the development of adult hypertension. Specifically, this research examined the effects of the

SUBMITTER: Lamothe J 

PROVIDER: S-EPMC7149440 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature