The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation.

ABSTRACT: N6-methyladenosine (m⁶A) is the richest modification in mammalian messenger RNAs (mRNAs), and exerts key roles in many biological processes, including cancer development, whereas its roles in prostate carcinoma (PCa) remain to be unclear. Here, we found that m⁶A modifications are increased in PCa and methyltransferase-like 3 (METTL3), but not other major m⁶A modification genes including METTL14, fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5), was the major dysregulated gene associated with abnormal m⁶A modification. In addition, METTL3 up-regulation acted as a poor prognostic factor for overall survival and disease-free survival in PCa patients. Knockdown of METTL3 significantly inhibited PCa cells proliferation, migrat

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC7150444 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature