Preliminary Report on the Effects of a Low Dose of LSD on Resting-State Amygdala Functional Connectivity.

ABSTRACT:

Background

The practice of "microdosing," or the use of repeated, very low doses of lysergic acid diethylamide (LSD) to improve mood or cognition, has received considerable public attention, but empirical studies are lacking. Controlled studies are needed to investigate both the therapeutic potential and the neurobiological underpinnings of this pharmacologic treatment.

Methods

The present study was designed to examine the effects of a single low dose of LSD (13 μg) versus placebo on resting-state functional connectivity and cerebral blood flow in healthy young adults. Twenty men and women, 18 to 35 years old, participated in 2 functional magnetic resonance imaging scanning sessions in which they received placebo or LSD under double-blind conditions. During each session, the

SUBMITTER: Bershad AK 

PROVIDER: S-EPMC7150630 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature