Functional Disruption of Cerebello-thalamo-cortical Networks in Obsessive-Compulsive Disorder.

ABSTRACT:

Background

Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive, compulsive behaviors. Neuroimaging studies have implicated altered connectivity among the functional networks of the cerebral cortex in the pathophysiology of OCD. However, there has been no comprehensive investigation of the cross-talk between the cerebellum and functional networks in the cerebral cortex.

Methods

This functional neuroimaging study was completed by 44 adult participants with OCD and 43 healthy control participants. We performed large-scale data-driven brain network analysis to identify functional connectivity patterns using resting-state functional magnetic resonance imaging data.

Results

Participants with OCD showed lower functional connectivity with

SUBMITTER: Sha Z 

PROVIDER: S-EPMC7150632 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature