Impaired counterregulatory responses to hypoglycaemia following oral glucose in adults with cystic fibrosis.

ABSTRACT:

Aims/hypothesis

The aim of this study was to determine the mechanism(s) for hypoglycaemia occurring late following oral glucose loading in patients with cystic fibrosis (CF).

Methods

A 3 h 75 g OGTT was performed in 27 non-diabetic adults with CF who were classified based on this test as experiencing hypoglycaemia (glucose <3.3 mmol/l with or without symptoms or glucose <3.9 mmol/l with symptoms, n = 14) or not (n = 13). Beta cell function, incretin (glucagon-like peptide-1 [GLP-1] and glucose-dependent insulinotropic peptide [GIP]) and counterregulatory hormone responses (glucagon, catecholamines, growth hormone and cortisol) were assessed.

Results

The two groups did not differ in age, weight or BMI. There were more male participants and individuals with pancreatic e

SUBMITTER: Aitken ML 

PROVIDER: S-EPMC7150633 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature