Alzheimer's disease pathology in APOE transgenic mouse models: The Who, What, When, Where, Why, and How.

ABSTRACT: The focus on amyloid plaques and neurofibrillary tangles has yielded no Alzheimer's disease (AD) modifying treatments in the past several decades, despite successful studies in preclinical mouse models. This inconsistency has caused a renewed focus on improving the fidelity and reliability of AD mouse models, with disparate views on how this improvement can be accomplished. However, the interactive effects of the universal biological variables of AD, which include age, APOE genotype, and sex, are often overlooked. Age is the greatest risk factor for AD, while the ε4 allele of the human APOE gene, encoding apolipoprotein E, is the greatest genetic risk factor. Sex is the final universal biological variable of AD, as females develop AD at almost twice the rate of males and, importantly, fema

SUBMITTER: Lewandowski CT 

PROVIDER: S-EPMC7150653 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature