Spray-Dried Amorphous Solid Dispersions of Griseofulvin in HPC/Soluplus/SDS: Elucidating the Multifaceted Impact of SDS as a Minor Component.

ABSTRACT: This study aimed to elucidate the impact of a common anionic surfactant, sodium dodecyl sulfate (SDS), along with hydroxypropyl cellulose (HPC) and Soluplus (Sol) on the release of griseofulvin (GF), a poorly soluble drug, from amorphous solid dispersions (ASDs). Solutions of 2.5% GF and 2.5%-12.5% HPC/Sol with 0.125% SDS/without SDS were prepared in acetone-water and spray-dried. The solid-state characterization of the ASDs suggests that GF-Sol had better miscibility and stronger interactions than GF-HPC and formed XRPD-amorphous GF, whereas HPC-based ASDs, especially the ones with a lower HPC loading, had crystalline GF. The dissolution tests show that without SDS, ASDs provided limited GF supersaturation (max. 250%) due to poor wettability of Sol-based ASDs and extensive GF recrystalliz

SUBMITTER: Rahman M 

PROVIDER: S-EPMC7150901 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature