The Influence of the Different Disposition Characteristics of Snake Toxins on the Pharmacokinetics of Snake Venom.

ABSTRACT: Snake venom is comprised of a combination of different proteins and peptides with a wide range of molecular weights and different disposition processes inherent to each compound. This causes venom to have a complex exposure profile. Our study investigates 1) how each molecular weight fraction (toxin) of venom contributes to the overall time course of the snake venom, and 2) the ability to determine toxin profiles based on the profile of the overall venom only. We undertook an in silico simulation and modelling study. Sixteen variations of venom, comprising of two to nine toxins with different molecular weights were investigated. The pharmacokinetic parameters (i.e., clearance,, and volume of distribution,) of each toxin were generated based on a log-linear relationship with molecular weigh

SUBMITTER: Sanhajariya S 

PROVIDER: S-EPMC7150903 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature