Timing of Heparin Administration Modulates Arterial Occlusive Thrombotic Response in Rats.

ABSTRACT: The timing for initiation of effective antithrombotic therapy relative to the onset of arterial thrombosis may influence outcomes. This report investigates the hypothesis that early administration of heparin anticoagulation relative to the onset of thrombotic occlusion will effect a reduction in occlusion. A standard rat model of experimental thrombosis induction was used, injuring the carotid artery exposure with FeCl3-saturated filter paper, followed by flow monitoring for onset of occlusion and subsequent embolization events. Intravenous heparin administration (200 units/mL) was timed relative to the initiation of injury or onset of near occlusion, compared with controls (no heparin administration). No occlusion was found for delivery of heparin 5 min prior to thrombus induction, wherea

SUBMITTER: Matrai AB 

PROVIDER: S-EPMC7151218 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature