Progesterone Receptor Gene Variants in Metastatic Estrogen Receptor Positive Breast Cancer.

ABSTRACT: Tumor mutations in the gene encoding estrogen receptor alpha (ESR1) have been identified in metastatic breast cancer patients with endocrine therapy resistance. However, relatively little is known about the occurrence of mutations in the progesterone receptor (PGR) gene in this population. The study objective was to determine the frequency and prognostic significance of tumor PGR mutations for patients with estrogen receptor (ER)-positive metastatic breast cancer. Thirty-five women with metastatic or locally recurrent ER+ breast cancer were included in this IRB-approved, retrospective study. Targeted next-generation sequencing of the PGR gene was performed on isolated tumor DNA. Associations between mutation status and clinicopathologic factors were analyzed as well as overall survival (OS

SUBMITTER: Fowler AM 

PROVIDER: S-EPMC7152560 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature