The Olfactory Bulb Provides a Radioresistant Niche for Glioblastoma Cells.

ABSTRACT:

Purpose

The various microenvironments that exist within the brain combined with the invasive nature of glioblastoma (GBM) creates the potential for a topographic influence on tumor cell radiosensitivity. The aim of this study was to determine whether specific brain microenvironments differentially influence tumor cell radioresponse.

Methods and materials

GBM stem-like cells were implanted into the right striatum of nude mice. To measure radiosensitivity, proliferation status of individual tumor cells was determined according to the incorporation of 5-chloro-2'-deoxyuridine delivered at 4, 12, and 20 days after brain irradiation. As an additional measure of radiosensitivity, the percentage of human cells in the right hemisphere and the olfactory bulb were defined using digita

SUBMITTER: Timme CR 

PROVIDER: S-EPMC7152565 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature