Mild behavioral impairment in Parkinson's disease is associated with altered corticostriatal connectivity.

ABSTRACT:

Background

Mild behavioral impairment (MBI) is a syndrome characterized by later life onset, sustained neuropsychiatric symptoms as a marker of dementia risk. In Parkinson's disease (PD), MBI has been associated with worse cognitive abilities and increased cortical atrophy. However, the circuit level correlates of MBI have not been investigated in this population. Our objective was to investigate the relationship between MBI and corticostriatal connectivity in PD patients. This emphasis on corticostriatal connectivity was due to the significant role of these circuits in neuropsychiatric and cognitive symptoms across disease conditions.

Methods

Seventy-four non-demented patients with PD were administered the MBI-checklist, and classified as having high MBI (PD-MBI; n = 21) or

SUBMITTER: Lang S 

PROVIDER: S-EPMC7152681 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature