Development of bone seeker-functionalised microspheres as a targeted local antibiotic delivery system for bone infections.

ABSTRACT:

Objective

Bone infections are challenging to treat because of limited capability of systemic antibiotics to accumulate at the bone site. To enhance therapeutic action, systemic treatments are commonly combined with local antibiotic-loaded materials. Nevertheless, available drug carriers have undesirable properties, including inappropriate antibiotic release profiles and nonbiodegradability. To alleviate such limitations, we aim to develop a drug delivery system (DDS) for local administration that can interact strongly with bone mineral, releasing antibiotics at the infected bone site.

Methods

Biodegradable polyesters (poly (ε-caprolactone) or poly (D,l-lactic acid)) were selected to fabricate antibiotic-loaded microspheres by oil in water emulsion. Antibiotic release and ant

SUBMITTER: Rotman SG 

PROVIDER: S-EPMC7152806 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature