Origin and transmission of Feline coronavirus type I in domestic cats from Northern Italy: a phylogeographic approach.

ABSTRACT: Feline coronavirus (FCoV) is responsible, along with an inadequate immune response of the host, for Feline infectious peritonitis (FIP), one of the most frequent and deadly infectious feline disease worldwide. This study analyzed the genetic characteristics of the spike (S) gene of 33 FCoVs circulating in Northern Italy between 2011 and 2015 in cats with or without FIP. In order to reconstruct the most probable places of origin and dispersion of FCoV among Italian cats, a phylogeographic approach was performed based on 106 FCoV S gene partial sequences from cats, including the 33 novel Italian sequences and 73 retrieved from public databases. Only FCoV type I was found in the Italian cats. The estimated mean evolutionary rate of FCoV was 2.4 × 10^-2 subs/site/year (95% HPD: 1.3-3

SUBMITTER: Lauzi S 

PROVIDER: S-EPMC7152909 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature