Low-Molecular-Weight Branched Polyethylenimine Potentiates Ampicillin against MRSA Biofilms.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) infections pose a serious threat worldwide. MRSA is the predominant species isolated from medical-device-related biofilm infections and chronic wounds. Its ability to form biofilms grants it resistance to almost all antibiotics on the market. Answering the call for alternative treatments, our lab has been investigating the efficacy of 600 Da branched polyethylenimine (BPEI) as a β-lactam potentiator against bacterial biofilms. Our previous study showed promise against methicillin-resistant Staphylococcus epidermidis biofilms. This study extends our previous findings to eradicate a more virulent pathogen: MRSA biofilms. Microtiter minimum biofilm eradication concentration models, crystal violet assays, and electron microscopy

SUBMITTER: Lam AK 

PROVIDER: S-EPMC7153015 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature