The orphan nuclear receptor estrogen-related receptor beta (ERRβ) in triple-negative breast cancer.

ABSTRACT:

Purpose

Triple-negative breast cancer (TNBC)/basal-like breast cancer (BLBC) is a highly aggressive form of breast cancer. We previously reported that a small molecule agonist ligand for the orphan nuclear receptor estrogen-related receptor beta (ERRβ or ESRRB) has growth inhibitory and anti-mitotic activity in TNBC cell lines. In this study, we evaluate the association of ESRRB mRNA, copy number levels, and protein expression with demographic, clinicopathological, and gene expression features in breast tumor clinical specimens.

Methods

ESRRB mRNA-level expression and clinical associations were analyzed using RNAseq data. Array-based comparative genomic hybridization determined ESRRB copy number in African-American and Caucasian women. Transcription factor activity was measu

SUBMITTER: Fernandez AI 

PROVIDER: S-EPMC7153462 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature