Near field non-invasive electrophysiology of retrotrapezoid nucleus using amperometric cation sensor.

ABSTRACT: Central chemoreception is the process whereby the brainstem senses blood gas levels and adjusts homeostatic functions such as breathing and cardiovascular tone accordingly. Rodent evidence suggests that the retrotrapezoid nucleus (RTN) is a master regulator of central chemoreception, in particular, through direct sensation of acidosis induced by CO₂ levels. The oscillatory dynamics caused by pH changes as sensed by the RTN surface and its relationship to the fluctuations in cation flux is not clearly understood due to the current limitations of electrophysiology tools and this article presents our investigations to address this need. A cation selective sensor fabricated from polypyrrole doped with dodecyl benzenesulfonate (PPy (DBS)) is placed over RTN in an ex-vivo en bloc brai

SUBMITTER: Gupta S 

PROVIDER: S-EPMC7153495 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature