Smoking and blood DNA methylation: an epigenome-wide association study and assessment of reversibility.

ABSTRACT: We conducted a genome-wide association study of blood DNA methylation and smoking, attempted replication of previously discovered associations, and assessed the reversibility of smoking-associated methylation changes. DNA methylation was measured in baseline peripheral blood samples for 5,044 participants in the Melbourne Collaborative Cohort Study. For 1,032 participants, these measures were repeated using blood samples collected at follow-up, a median of 11 years later. A cross-sectional analysis of the association between smoking and DNA methylation and a longitudinal analysis of changes in smoking status and changes in DNA methylation were conducted. We used our cross-sectional analysis to replicate previously reported associations for current (N = 3,327) and former (N = 172) smoking.

SUBMITTER: Dugue PA 

PROVIDER: S-EPMC7153547 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature