A 7-lncRNA signature associated with the prognosis of colon adenocarcinoma.

ABSTRACT:

Background

Colon adenocarcinoma (COAD) is the most common colon cancer exhibiting high mortality. Due to their association with cancer progression, long noncoding RNAs (lncRNAs) are now being used as prognostic biomarkers. In the present study, we used relevant clinical information and expression profiles of lncRNAs originating from The Cancer Genome Atlas database, aiming to construct a prognostic lncRNA signature to estimate the prognosis of patients.

Methods

The samples were randomly spilt into training and validation cohorts. In the training cohort, prognosis-related lncRNAs were selected from differentially expressed lncRNAs using the univariate Cox analysis. Furthermore, the least absolute shrinkage and selection operator (LASSO) regression and multivariate Cox analysi

SUBMITTER: Fu X 

PROVIDER: S-EPMC7153553 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature