Intein mediated high throughput screening for bispecific antibodies.

ABSTRACT: Bispecific antibodies comprise extremely diverse architectures enabling complex modes of action, such as effector cell recruitment or conditional target modulation via dual targeting, not conveyed by monospecific antibodies. In recent years, research on bispecific therapeutics has substantially grown. However, evaluation of binding moiety combinations often leads to undesired prolonged development times. While high throughput screening for small molecules and classical antibodies has evolved into a mature discipline in the pharmaceutical industry, dual-targeting antibody screening methodologies lack the ability to fully evaluate the tremendous number of possible combinations and cover only a limited portion of the combinatorial screening space. Here, we propose a novel combinatorial screen

SUBMITTER: Hofmann T 

PROVIDER: S-EPMC7153837 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature