The immunosuppressive phenotype of tumor-infiltrating neutrophils is associated with obesity in kidney cancer patients.

ABSTRACT: Infiltrating tumor neutrophils and myeloid-derived suppressor cells represent major populations in the tumor microenvironment that contribute to tumor progression. However, the phenotype of circulating and tumor-associated neutrophils, and the impact of cancer patients' metabolic state on neutrophil function need further characterization. Here we show that in kidney cancer patients, circulating neutrophils display an altered immature-like phenotype, and an activated/primed metabolic state. Circulating immature-like neutrophils acquire an activated phenotype upon migration into the tumor tissue, characterized by high expression of the immunosuppressive enzyme arginase-1, and active granule release. Interestingly, obesity and adipose tissue distribution were significantly associated with thi

SUBMITTER: Margaroli C 

PROVIDER: S-EPMC7153842 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature