Predicting Antibody Developability Profiles Through Early Stage Discovery Screening.

ABSTRACT: Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term 'developability' encompasses the feasibility of molecules to successfully progress from discovery to development via evaluation of their physicochemical properties. These properties include the tendency for self-interaction and aggregation, thermal stability, colloidal stability, and optimization of their properties through sequence engineering. Selection of the best antibody molecule based on biological function, efficacy, safety, and developability allows for a streamlined and successful CMC phase. An efficient and practical high-throughput developability workflow (100 s-1,000 s of molecules) implemented during early antibody generation and screening is cruci

SUBMITTER: Bailly M 

PROVIDER: S-EPMC7153844 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature