Evolution of Distinct Responses to Low NAD⁺ Stress by Rewiring the Sir2 Deacetylase Network in Yeasts.

ABSTRACT: Evolutionary adaptation increases the fitness of a species in its environment. It can occur through rewiring of gene regulatory networks, such that an organism responds appropriately to environmental changes. We investigated whether sirtuin deacetylases, which repress transcription and require NAD⁺ for activity, serve as transcriptional rewiring points that facilitate the evolution of potentially adaptive traits. If so, bringing genes under the control of sirtuins could enable organisms to mount appropriate responses to stresses that decrease NAD⁺ levels. To explore how the genomic targets of sirtuins shift over evolutionary time, we compared two yeast species, Saccharomyces cerevisiae and Kluyveromyces lactis, that display differences in cellular metabo

SUBMITTER: Humphrey KM 

PROVIDER: S-EPMC7153948 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature