Modulation of the cardiac Na⁺-Ca²⁺ exchanger by cytoplasmic protons: Molecular mechanisms and physiological implications.

ABSTRACT: A precise temporal and spatial control of intracellular Ca²⁺ concentration is essential for a coordinated contraction of the heart. Following contraction, cardiac cells need to rapidly remove intracellular Ca²⁺ to allow for relaxation. This task is performed by two transporters: the plasma membrane Na⁺-Ca²⁺ exchanger (NCX) and the sarcoplasmic reticulum (SR) Ca²⁺-ATPase (SERCA). NCX extrudes Ca²⁺ from the cell, balancing the Ca²⁺entering the cytoplasm during systole through L-type Ca²⁺ channels. In parallel, following SR Ca²⁺ release, SERCA activity replenishes the SR, reuptaking Ca²⁺ from the cytoplasm. The activity of the mammalian exchanger is fine-tuned by numerous ionic allost

SUBMITTER: Scranton K 

PROVIDER: S-EPMC7153995 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature