Anti-MRSA Activity of Actinomycin X₂ and Collismycin A Produced by Streptomyces globisporus WA5-2-37 From the Intestinal Tract of American Cockroach (Periplaneta americana).

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as one of the serious pathogen that causes acquired infections worldwide. Its emerging need to discover novel, safe and potent anti-MRSA drugs. In this study, primary screening by anti-MRSA activity assay found one strain WA5-2-37 isolated from the intestinal tract of Periplaneta americana, exhibited great activity against MRSA ATCC 43300. The strain WA5-2-37 produced actinomycin X₂ and collismycin A which showed strong inhibition of MRSA with minimum inhibitory concentration (MIC) values of 0.25 and 8 μg/mL. The structures of the pure compounds were elucidated by analysis of mass spectrometry (MS), ¹H and ¹³C nuclear magnetic resonance (NMR). The strain WA5-2-37 was considered a

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7154055 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature