Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes.

ABSTRACT: The screening and testing of extracts against a variety of pharmacological targets in order to benefit from the immense natural chemical diversity is a concern in many laboratories worldwide. And several successes have been recorded in finding new actives in natural products, some of which have become new drugs or new sources of inspiration for drugs. But in view of the vast amount of research on the subject, it is surprising that not more drug candidates were found. In our view, it is fundamental to reflect upon the approaches of such drug discovery programs and the technical processes that are used, along with their inherent difficulties and biases. Based on an extensive survey of recent publications, we discuss the origin and the variety of natural chemical diversity as well as the stra

SUBMITTER: Lautie E 

PROVIDER: S-EPMC7154113 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature