Treatment of Renal Anemia with Roxadustat: Advantages and Achievement.

ABSTRACT:

Background

Although renal anemia has attracted widespread attention, a large proportion of chronic kidney disease (CKD) patients with anemia still do not meet the hemoglobin (Hb) targets. The discovery of prolyl hydroxylase domain (PHD) enzymes as regulators of hypoxia-inducible factor (HIF)-dependent erythropoiesis has led to the development of novel therapeutic agents for renal anemia. Roxadustat, the first small-molecule HIF-PHD inhibitor, has completed the phase 3 trials. There are currently more than 15 phase 3 clinical trials worldwide assessing the efficacy and safety of roxadustat in CKD patients with anemia. This review will summarize recent findings of roxadustat in the treatment of renal anemia.

Summary

Although the administration of erythropoiesis-stimulating age

SUBMITTER: Li ZL 

PROVIDER: S-EPMC7154284 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature