Identification of HO-1 as a novel biomarker for graft acute cellular rejection and prognosis prediction after liver transplantation.

ABSTRACT:

Background

Liver transplantation (LT) is the most effective treatment for patients with end-stage liver diseases, but acute rejection is still a major concern. However, the mechanisms underlying rejection remain unclear. Biomarkers are lacking for predicting rejection and long-term survival after LT.

Methods

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics was performed between acute cellular rejection (ACR) and non-rejection recipients. The molecular signature differences and potential biomarkers were identified by comprehensive bioinformatics. Heme oxygenase-1 (HO-1) expression and its association with clinical outcomes were investigated by tissue microarrays consisted of liver specimens from recipients with (n=80) and without ACR (n=57).

Re

SUBMITTER: Jia J 

PROVIDER: S-EPMC7154463 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature