MRI profiling of focal cortical dysplasia using multi-compartment diffusion models.

ABSTRACT:

Objective

Focal cortical dysplasia (FCD) lesion detection and subtyping remain challenging on conventional MRI. New diffusion models such as the spherical mean technique (SMT) and neurite orientation dispersion and density imaging (NODDI) provide measurements that potentially produce more specific maps of abnormal tissue microstructure. This study aims to assess the SMT and NODDI maps for computational and radiological lesion characterization compared to standard fractional anisotropy (FA) and mean diffusivity (MD).

Methods

SMT, NODDI, FA, and MD maps were calculated for 33 pediatric patients with suspected FCD (18 histologically confirmed). Two neuroradiologists scored lesion visibility on clinical images and diffusion maps. Signal profile changes within lesions and homolog

SUBMITTER: Lorio S 

PROVIDER: S-EPMC7154549 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature