NRF2 activation with Protandim attenuates salt-induced vascular dysfunction and microvascular rarefaction.

ABSTRACT:

Hypothesis

This study tested the hypothesis that dietary activation of the master antioxidant and cell protective transcription factor nuclear factor, erythroid -2-like 2 (NRF2), protects against salt-induced vascular dysfunction by restoring redox homeostasis in the vasculature.

Methods

Male Sprague-Dawley rats and Syrian hamsters were fed a HS (4.0% NaCl) diet containing ~60 mg/kg/day Protandim supplement for 2 weeks and compared to controls fed HS diet alone.

Results

Protandim supplementation restoredendothelium-dependent vasodilation in response to acetylcholine (ACh) in middle cerebral arteries (MCA)of HS-fed rats and hamster cheek pouch arterioles, and increased microvessel density in the cremastermuscle of HS-fed rats. The restored dilation to ACh in MCA of Pro

SUBMITTER: Priestley JRC 

PROVIDER: S-EPMC7154587 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature