Changes in thalamic dopamine innervation in a progressive Parkinson's disease model in monkeys.

ABSTRACT:

Background

Dopamine loss beyond the mesostriatal system might be relevant in pathogenic mechanisms and some clinical manifestations in PD. The primate thalamus is densely and heterogeneously innervated with dopaminergic axons, most of which express the dopamine transporter, as does the nigrostriatal system. We hypothesized that dopamine depletion may be present in the thalamus of the parkinsonian brain and set out to ascertain possible regional differences.

Methods

The toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was administered to adult macaque monkeys using a slow intoxication protocol. The treated macaques were classified into 2 groups according to their motor status: nonsymptomatic and parkinsonian. Dopamine innervation was studied with immunohistochemistry for th

SUBMITTER: Monje MHG 

PROVIDER: S-EPMC7154739 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature