Association of Cigarette Smoking With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

ABSTRACT:

Importance

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small vessel vasculitis characterized by circulating ANCAs targeting proteinase 3 (PR3) or myeloperoxidase (MPO) and associated with excess morbidity and mortality. Myeloperoxidase-ANCA-positive AAV and PR3-ANCA-positive AAV are increasingly recognized to have differences in genetic risk, pathogenesis, and response to treatment. Risk factors for AAV, including cigarette smoking, are poorly understood.

Objective

To examine the association between cigarette smoking and AAV.

Design, setting, and participants

This case-control study included a consecutive inception cohort of 484 patients with AAV diagnosed from 2002 to 2017 compared with a cohort of sex-, race-, and age-matched

SUBMITTER: McDermott G 

PROVIDER: S-EPMC7154954 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature