Electrophotocatalytic Undirected C-H Trifluoromethylations of (Het)Arenes.

ABSTRACT: Electrophotochemistry has enabled arene C-H trifluoromethylation with the Langlois reagent CF₃ SO₂ Na under mild reaction conditions. The merger of electrosynthesis and photoredox catalysis provided a chemical oxidant-free approach for the generation of the CF₃ radical. The electrophotochemistry was carried out in an operationally simple manner, setting the stage for challenging C-H trifluoromethylations of unactivated arenes and heteroarenes. The robust nature of the electrophotochemical manifold was reflected by a wide scope, including electron-rich and electron-deficient benzenes, as well as naturally occurring heteroarenes. Electrophotochemical C-H trifluoromethylation was further achieved in flow with a modular electro-flow-cell equipped with an in-ope

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC7155051 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature