Risk factors for progression of age-related macular degeneration.

ABSTRACT:

Purpose

Age-related macular degeneration (AMD) is a degenerative disease of the macula, often leading to progressive vision loss. The rate of disease progression can vary among individuals and has been associated with multiple risk factors. In this review, we provide an overview of the current literature investigating phenotypic, demographic, environmental, genetic, and molecular risk factors, and propose the most consistently identified risk factors for disease progression in AMD based on these studies. Finally, we describe the potential use of these risk factors for personalised healthcare.

Recent findings

While phenotypic risk factors such as drusen and pigment abnormalities become more important to predict disease progression during the course of the disease, demographic

SUBMITTER: Heesterbeek TJ 

PROVIDER: S-EPMC7155063 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature