Cerebral oxygen metabolism in adults with sickle cell disease.

ABSTRACT: In sickle cell disease (SCD), oxygen delivery is impaired due to anemia, especially during times of increased metabolic demand, and cerebral blood flow (CBF) must increase to meet changing physiologic needs. But hyperemia limits cerebrovascular reserve (CVR) and ischemic risk prevails despite elevated CBF. The cerebral metabolic rate of oxygen (CMRO₂ ) directly reflects oxygen supply and consumption and may therefore be more insightful than flow-based CVR measures for ischemic risk in SCD. We hypothesized that adults with SCD have impaired CMRO₂ at rest and that a vasodilatory challenge with acetazolamide would improve CMRO₂ . CMRO₂ was calculated from CBF and oxygen extraction fraction (OEF), measured with arterial spin labeling and T₂

SUBMITTER: Vaclavu L 

PROVIDER: S-EPMC7155077 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature