Menstrual and obstetrical bleeding in women with inherited platelet receptor defects-A systematic review.

ABSTRACT: INTRODUCTION:Women with inherited platelet receptor defects (IPRD) may have an increased risk of heavy menstrual bleeding (HMB) and postpartum haemorrhage (PPH). AIM:To present a systematic overview of the literature on the prevalence and management of menstrual and obstetrical bleeding in women with IPRD. METHODS:Electronic databases were searched for original patient data on the prevalence and management of HMB and PPH in women with known IPRD or who were being investigated for IPRD. RESULTS:Sixty-nine papers (61 case reports/series and 8 cohort studies) were included. Overall, studies were rated as 'poor quality'. The included cohort studies reported HMB in 25% (13/52) of women with Bernard-Soulier syndrome and in 22.1% (34/154) of women with Glanzmann thrombasthenia. In total, 164 deli

SUBMITTER: Punt MC 

PROVIDER: S-EPMC7155109 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature