Aberrant structural covariance networks in youth at high familial risk for mood disorder.

ABSTRACT:

Objectives

Current research suggests significant disruptions in functional brain networks in individuals with mood disorder, and in those at familial risk. Studies of structural brain networks provide important insights into synchronized maturational change but have received less attention. We aimed to investigate developmental relationships of large-scale brain networks in mood disorder using structural covariance (SC) analyses.

Methods

We conducted SC analysis of baseline structural imaging data from 121 at the time of scanning unaffected high risk (HR) individuals (29 later developed mood disorder after a median time of 4.95 years), and 89 healthy controls (C-well) with no familial risk from the Scottish Bipolar Family Study (age 15-27, 64% female). Voxel-wise analyses of

SUBMITTER: Heinze K 

PROVIDER: S-EPMC7155114 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature