Tubular scaffold with microchannels and an H-shaped lumen loaded with bone marrow stromal cells promotes neuroregeneration and inhibits apoptosis after spinal cord injury.

ABSTRACT: As a result of its complex histological structure, regeneration patterns of grey and white matter are quite different in the spinal cord. Therefore, tissue engineering scaffolds for repairing spinal cord injury must be able to adapt to varying neural regeneration patterns. The aim of the present study was to improve a previously reported spinal cord-mimicking partition-type scaffold by adding microchannels on a single tubular wall along its longitudinal axis, thus integrating the two architectures of a single H-shaped central tube and many microchannels. Next, the integrated scaffold was loaded with bone marrow stromal cells (BMSCs) and transplanted to bridge the 5-mm defect of a complete transverse lesion in the thoracic spinal cord of rats. Subsequently, effects on nerve regeneration, lo

SUBMITTER: Chen X 

PROVIDER: S-EPMC7155140 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature