Preferential Perinatal Development of Skin-Homing NK1.1⁺ Innate Lymphoid Cells for Regulation of Cutaneous Microbiota Colonization.

ABSTRACT: Proper immune cell development at early ontogenic stages is critical for life-long health. How resident immune cells are established in barrier tissues at neonatal stages to provide early protection is an important but still poorly understood question. We herein report that a developmentally programmed preferential generation of skin-homing group 1 innate lymphoid cells (ILC1s) at perinatal stages helps regulate early skin microbiota colonization. We found that a population of skin-homing NK1.1⁺ ILC1s was preferentially generated in the perinatal thymi of mice. Unique thymic environments and progenitor cells are responsible for the preferential generation of skin-homing NK1.1⁺ ILC1s at perinatal stages. In the skin, NK1.1⁺ ILC1s regulate proper microbiota c

SUBMITTER: Yang J 

PROVIDER: S-EPMC7155142 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature