The Impact of Global Transcriptional Regulation on Bacterial Gene Order.

ABSTRACT: Bacterial gene expression depends on the allocation of limited transcriptional resources provided a particular growth rate and growth condition. Early studies in a few genes suggested this global regulation to generate a unifying hyperbolic expression pattern. Here, we developed a large-scale method that generalizes these experiments to quantify the response to growth of over 700 genes that a priori do not exhibit any specific control. We distinguish a core subset following a promoter-specific hyperbolic response. Within this group, we sort genes with regard to their responsiveness to the global regulatory program to show that those with a particularly sensitive linear response are located near the origin of replication. We then find evidence that this genomic architecture is biologically

SUBMITTER: Yubero P 

PROVIDER: S-EPMC7155222 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature