Dataset Information

Human signal transducer and activator of transcription 5b (STAT5b) mutation causes dysregulated human natural killer cell maturation and impaired lytic function.

ABSTRACT:

Background

Patients with signal transducer and activator of transcription 5b (STAT5b) deficiency have impairment in T-cell homeostasis and natural killer (NK) cells which leads to autoimmunity, recurrent infections, and combined immune deficiency.

Objective

In this study we characterized the NK cell defect in STAT5b-deficient human NK cells, as well as Stat5b^-/- mice.

Methods

We used multiparametric flow cytometry, functional NK cell assays, microscopy, and a Stat5b^-/- mouse model to elucidate the effect of impaired and/or absent STAT5b on NK cell development and function.