Update of screening and diagnostic modalities for connective tissue disease-associated pulmonary arterial hypertension.

ABSTRACT:

Objective

Pulmonary arterial hypertension (PAH) has high morbidity and mortality in connective tissue diseases (CTDs), especially systemic sclerosis (SSc). In this systematic review, we provide an update on screening measures for early detection of PAH in CTD.

Methods

Manuscripts published between July 2012 and October 2017, which incorporated screening measures to identify patients with PAH by right heart catheterization, were identified. Risk of bias was assessed using the QUADAS-2 tool.

Results

The systematic review resulted in 1514 unique citations and 22 manuscripts were included for final review; the majority of manuscripts had a lower risk of bias based on the QUADAS-2 tool. There were 16 SSc cohort studies and 6 case-control studies (SSc 4, SLE 2). Four SSc co

SUBMITTER: Young A 

PROVIDER: S-EPMC7155785 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature