CD45RB Status of CD8⁺ T Cell Memory Defines T Cell Receptor Affinity and Persistence.

ABSTRACT: The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8⁺ T pool is unexpectedly comprised of both CD45RB^hi and CD45RB^lo populations. Relative to CD45RB^lo memory T cells, CD45RB^hi memory T cells have lower affinity and display greater clonal diversity, as well as a persistent CD27^hi phenotype. The CD45RB^hi memory population displays a homeostatic survival advantage in vivo relative to CD45RB^lo memory, and long-lived high-affinity cells that persisted long term convert from CD45RB^lo to CD45RB^hi. Human CD45RO⁺ memory is comprised of both C

SUBMITTER: Krummey SM 

PROVIDER: S-EPMC7155808 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature