Cascade trifluoromethylthiolation and cyclization of N-[(3-aryl)propioloyl]indoles.

ABSTRACT: A cascade oxidative trifluoromethylthiolation and cyclization of N-[(3-aryl)propioloyl]indoles with AgSCF₃ is described. This protocol allows for the synthesis of novel bis(trifluoromethylthiolated) or trifluoromethylthiolated pyrrolo[1,2-a]indol-3-ones in moderate to good yields. Mechanistic investigations indicated that radical processes were probably involved in these transformations.

SUBMITTER: Bi MX 

PROVIDER: S-EPMC7155893 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature