Differential gene expression during placentation in pregnancies conceived with different fertility treatments compared with spontaneous pregnancies.

ABSTRACT:

Objective

To identify differences in the transcriptomic profiles during placentation from pregnancies conceived spontaneously vs. those with infertility using non-in vitro fertilization (IVF) fertility treatment (NIFT) or IVF.

Design

Cohort study.

Setting

Academic medical center.

Patient(s)

Women undergoing chorionic villus sampling at gestational age 11-13 weeks (n = 141), with pregnancies that were conceived spontaneously (n = 74), with NIFT (n = 33), or with IVF (n = 34), resulting in the delivery of viable offspring.

Intervention(s)

Collection of chorionic villus samples from women who conceived spontaneously, with NIFT, or with IVF for gene expression analysis using RNA sequencing.

Main outcome measure(s)

Baseline maternal, paternal, and feta

SUBMITTER: Lee B 

PROVIDER: S-EPMC7156023 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature