Priming exposures to lipopolysaccharides do not affect the induction of Polycomb target genes upon re-exposure.

ABSTRACT: The Polycomb group (PcG) proteins are chromatin factors underlying the process of transcriptional memory to preserve developmental decisions and keep cellular identities. However, not only developmental signals need to be memorized and thus maintained during the life of an organism. For host protection against pathogens, also a memory of previous exposures to an immunogenic stimulus is crucial to mount a more protective immune response upon re-exposure. The antigen-specific adaptive immunity in vertebrates is an example of such a memory to previous immunogenic stimulation. Recently, adaptive characteristics were also attributed to innate immunity, which was classically seen to lack memory. However, the mechanistic details of an adaptive innate immune response are yet to be fully understood

SUBMITTER: Geigges M 

PROVIDER: S-EPMC7156044 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature